Augmentin oral
Penicillin is only available in combination with an oral inhibitor of beta-lactamase is amoxicillin-clavulanic acid (also called amoxicillin- clavulanate). This combination has been invented by British scientists working at Beecham.
Clavulanic acid is a beta-lactam, structurally related to penicillin, which has the ability to inactivate a wide range of beta-lactamase enzymes commonly found in micro-organisms resistant to penicillins and cephalosporins. In particular, it has good activity against clinically important beta-lactamase plasmid frequently responsible resistance transferred.
The combination of amoxicillin, a beta-lactam antibiotics, clavulanic acid, an inhibitor of beta lactamase results in a broad spectrum antibiotic action and restore the efficacy against beta-lactamase-producing bacteria resistant to amoxicillin. This drug offers a wider coverage of the antimicrobial beta-lactamase producing strains of S. aureus, H. influenzae, N. gonorrhoeae, E. coli M. catarrhalis and Proteus, Klebsiella and Bacteroides species. A low activity against Pseudomonas or methicillin-resistant S. aureus.
In addition, broad spectrum of activity increases antimicrobal of amoxicillin / clavulanic acid, the risk of developing resistance.
In situations clinics where there is an increase in the development of organisms producing beta-lactamase, amoxicillin-clavulanic acid may be the first choice for the treatment of otitis media, sinusitis, bronchitis, urinary tract infections and infections of skin and soft tissue. Amoxicillin-clavulanate is ideal drug for the treatment of infections caused by human and animal bites.
The most common side effects, amoxicillin-clavulanic acid include diarrhea (alleviated by taking the medication with food or water), nausea, rash Skin and superinfection with Candida.
The main drawback of target = "_new" rel = "nofollow" href = "http://www.emedexpert.com/facts/amoxicillin-clavulanate-facts.shtml> amoxicillin "/ Clavulanate is an increase in the rate of gastrointestinal side effects than amoxicillin alone. This medicine may cause extensive range of liver lesions including intrahepatic cholestasis without hepatocellular injury and acute hepatitis cholestatic hepatitis with hepatocellular necrosis. The most important factor is the age of susceptibility over 65 years.
Amoxicillin-clavulanic acid is more expensive than amoxicillin.
Yury Bayarski is the contributing author of eMedExpert.com.
More information about Augmentin [http://www.emedexpert.com/products/augmentin.shtml] is available on author’s website.
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